The AZURA Cannabis Purifier is a dedicated preparative system to purify cannabinoids from cannabis extracts. The HPLC layout consists of a pump with ternary LPG valve block and a HPLC docking station equipped with a variable single wavelength UV detector an injection and a fractionation valve for 11 fractions and waste. The system is designed for method development und small volumes of sample in a flow rate range between 10 to 80 ml/min at maximum 400 bar. The system is controlled by the intuitive and touch-optimized Mobile Control, which is installed on a tablet. The software has a simple function for threshold based fractionation. Depending on the value of the detector signal the target substances/peaks are collected automatically. The purification of CBD from a cannabinoid oil is shown exemplarily.