Choosing FlexiPro™ TFF for Scalable, High-Performance Bioprocessing

Tangential Flow Filtration (TFF) is a critical step in downstream bioprocessing, supporting concentration, diafiltration, and buffer exchange while protecting product quality. As processes move faster and become more flexible, manufacturers need TFF systems that scale easily and perform reliably.
 
Building on this need for reliable scalability, FlexiPro™ TFF systems from VERDOT  enable gentle, efficient single-use filtration and seamless multi-scale processing from development through GMP manufacturing.

Multi-Purpose TFF for Modern Downstream Workflows

FlexiPro™ TFF is a multi-purpose filtration platform that supports a wide range of downstream applications, including protein concentration and buffer exchange. With this adaptability, teams can use a single system across multiple molecules and processes. 

Compatible with Any Filtration Format

FlexiPro™ TFF offers maximum flexibility, supporting any filtration format. This enables process scientists to choose the membrane type and configuration best suited to their application—without being locked into a single option.
 
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Configurable and Scalable by Design

Taking configurability to the next level, FlexiPro™ TFF systems enable easy transition from small-scale to GMP manufacturing, simplifying tech transfer and reducing risk.

Change the Flow Kit — Not the System

The single-use FlexiPro™ TFF system delivers true flexibility with a four-skids-in-one design, allowing you to scale from 1 LPH to 3,500 LPH in under 15 minutes—simply by changing the flow kit.

1 LPH → 3,500 LPH
One system. Four flow ranges. < 15 minutes to scale.


FlexiPro™ TFF Flow Kit Overview

Flow Kit Flow Range (LPH) Membrane Surface Area (m²) Typical Application
VLFK 1 – 30 0.002 – 0.06 R&D & early development
LFK 5 – 170 0.007 – 1.0 Process optimization
HFK 25 – 1,150 0.05 – 5.1 Pilot & scale-up
VHFK 100 – 3,500 0.16 – 34.0 GMP & commercial production

Why It Matters

  • Replace multiple TFF skids with one scalable system
  • Reduce footprint, capital cost, and validation effort
  • Maintain consistent process behavior across scales
  • Adapt instantly as production demands change

Precision and Intuitive Control

Alongside scalability, precise control of filtration parameters ensures consistent, efficient operation with maintained product integrity.

Flexible Single-Use Advantage

In addition to its intuitive operation, the single-use design minimizes cleaning validation, reduces downtime, and lowers contamination risk—making FlexiPro™ TFF an ideal solution for facilities requiring fast changeovers and flexible production schedules.

How GMI Supports FlexiPro™ TFF

Given these advantages, process scientists are switching to FlexiPro™ TFF for its balance of flexibility, precision, and scalability, delivering high-performance TFF without the operational burden of traditional systems.
 
To ensure the success of your implementation, GMI partners with VERDOT to help customers successfully implement FlexiPro™ TFF systems, providing expert guidance, application support, and reliable service throughout the system lifecycle.
 
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Move Your Downstream Filtration Forward

👉 Learn why process scientists are choosing FlexiPro™ TFF:
https://www.gmi-inc.com/wp-content/uploads/2025/12/Verdot-FlexiPro-TFF-1080×1080-RGB-AW.pdf
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