New Laboratory Equipment, VERDOT
Watch the VERDOT FlexiPro™ TFF System in Action
Jan
A Quick Overview of FlexiPro™ TFF Technology
Tangential Flow Filtration (TFF) is a critical step in downstream bioprocessing—supporting clarification, concentration, diafiltration, and buffer exchange while protecting product quality. As biopharmaceutical processes scale faster and become more flexible, manufacturers need TFF systems that deliver consistent performance from development through GMP manufacturing.
The FlexiPro™ TFF System from VERDOT meets these demands with a single-use platform designed for seamless multi-scale operation and intuitive control.
One System for Every Filtration Step
FlexiPro™ TFF supports all downstream filtration steps—from harvest clarification through concentration, diafiltration, and final formulation—using a single, scalable system. Designed to move seamlessly from pilot-scale processing to full GMP manufacturing, FlexiPro™ TFF eliminates the need for multiple filtration skids.
Scalability is achieved through interchangeable single-use flow kits paired with modular pump heads, allowing users to scale from 1 to 3,500 LPH in under 15 minutes—simply by changing the flow kit.
1 LPH → 3,500 LPH
One system. Four flow ranges. < 15 minutes to scale.
FlexiPro™ TFF Flow Kit Overview
| Flow Kit | Flow Range (LPH) | Membrane Surface Area (m²) | Typical Application for mAbs and rProteins |
|---|---|---|---|
| VLFK | 1 – 30 | 0.002 – 0.06 | R&D & early development |
| LFK | 5 – 170 | 0.007 – 1.0 | Process optimization |
| HFK | 25 – 1,150 | 0.05 – 5.1 | Pilot & scale-up |
| VHFK | 100 – 3,500 | 0.16 – 34.0 | GMP & commercial manufacturing |
Precision Control for Consistent Performance
FlexiPro™ TFF uses proprietary pressure control valves to precisely regulate transmembrane pressure and flow—parameters critical for maximizing flux while minimizing fouling and aggregation. High-precision instrumentation delivers benchtop-level accuracy in a single-use format, providing reliable process insight and reproducible performance at every scale.
Built for Ease and Confidence
Ease of use is built into every aspect of FlexiPro™ TFF. Pre-assembled, gamma-irradiated flow kits, directional guides, and a transparent door make setup fast and mistake-proof. Operators can visually confirm correct fluid path installation, and flow kit changes are completed in less than 15 minutes using a simple Allen wrench.
This intuitive design reduces downtime, shortens training time, and supports fast, confident changeovers.
Flexible by Design
FlexiPro™ TFF is compatible with flat sheet cassettes and hollow fiber membranes, giving process teams the freedom to select the filtration format that best fits their application. The system supports full automation using onboard control software or your preferred control platform, allowing seamless integration into existing workflows.
How GMI Supports FlexiPro™ TFF
As a trusted partner for advanced bioprocessing solutions, GMI supports FlexiPro™ TFF system selection, configuration, and long-term success. From application guidance and system setup to service and ongoing support, GMI helps ensure your downstream filtration process performs reliably at every stage.
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