Only logged in customers who have purchased this product may leave a review.
Campden Instruments has collaborated with leading researchers across various research disciplines to build a vibratome that meets real-world laboratory challenges. Find confidence and precision with the 9000SMZ.
✔ Confidence from the very first cut
Dr. Gareth Morris of University of Manchester and University College London talks about his research and how the use of Brain Slices provides an invaluable, in vitro research tool.
Dr. Kate Connor from Trinity College Dublin talks about her research into the development of clinically relevant cancer models and the use of brain slices for model validation.
Neuronal oscillations in the theta frequency range (4 – 8 Hz) induced by the acetylcholine muscarinic receptor agonist carbachol (50 μM) in hippocampal area CA3 from 3 week-old C57BL/6J mice. Slices were either incubated in control aCSF or in aCSF supplemented with sonicated recombinant human tau preformed fibrils (133 nM; rPeptide; CF-1001-1).
Left panels: raw electrophysiological traces showing induction of oscillations after carbachol, and 25 s of activity (red boxed region; lower traces).
Right panels: spectrograms of theta activity induced by carbachol in both conditions.
Source: Adwoa Boaten, Ben Hopkins, Tegan Lawrence, Beth Rees, Amol Bhandare, Stuart Greenhill, Gavin Woodhall, Mark Wall, Bruno Frenguelli School of Life Sciences, University of Warwick, Coventry, UK CV4 7AL. Institute of Health and Neurodevelopment, Aston University, Birmingham, UK B4 7ET
Improved microtome design allows neuronal preservation and physiological oscillations in older rats (9 months). Here we show DIC images from entorhinal cortex and area CA1.
(A) Raw electrophysiological data at increasing magnification demonstrating characteristic spontaneous sawtooth gamma oscillations in LFP recordings (450 μm slice).
(B) Panel shows example FFT from LFP recording in hippocampus with no added drugs, with high power in gamma range and excellent coherence.
(C) Whole-cell patch-clamp recording from hippocampal cell with regular EPSCs and stable baseline (350 μm slice).
Only logged in customers who have purchased this product may leave a review.
Reviews
There are no reviews yet.