Agilent 1100 LC/MSD with Model G1946D mass spectrometer.
Agilent 1100 G1956D LC MS refurbished to specifications, ESI source, roughing pump, complete data system. *Professional installation available.
In 1997 HP introduces its first benchtop quadrupole LC/MS the 1100 Series LC/MSD. The 1100 Series LC/MSD provides information quickly in one chromatographic run. It provides molecular weight structural information and has excellent selectivity needed to identify compounds check the purity of chromatographic peaks and quantitate trace level samples in complex matrices in a rugged reliable easy-to-use benchtop system. For chromatographers and mass spectrometrists who need the utmost in sensitivity the LC/MSD SL makes analyses in the very low picogram range possible*
The 1100 Series LC/MSD offers many advantages as an LC detector. It offers the dynamic range and repeatability needed for most quantitative applications. In the SIM mode it offers high sensitivity. For compounds lacking a strong chromophore it offers detection limits not possible with other detectors. By offering unit mass resolution to m/z 3000 the LC/MSD allows for characterization of large proteins beyond 60000 KDalton. Having extended mass range to 3000 is also beneficial when studying modified proteins such as glycoproteins where their charge distribution falls above m/z 2000.
The Agilent 1100 Series LC/MSD is a benchtop mass spectrometer designed to be integrated with the 1100 Series HPLC System. It is a quadrupole based atmospheric pressure ionization (API) instrument capable of doing both electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI). The LC/MSD can handle normal HPLC flow rates (1 ml/min) without splitting the effluent and with minimal adjustment of the spray chamber.
- Agilent/HP 1100 Series G1312A Binary Pump
- Agilent/HP 1100 Series G1313 Autosampler
- Agilent/HP 1100 Series G1316A Column compartment
- Agilent/HP 1100 Series G1322A Degasser and Solvent tray
- More Configurations available
Mass spectrometry plays an important role in the entire life cycle of a drug from discovery to development to manufacturing. In drug discovery LC/MS systems are the method of choice for identifying and characterizing of drug candidates produced by combinatorial chemistry or extracted from natural products. They are also a primary tool used to check drug compound quality during manufacturing.
Proteomics is the large-scale analysis of proteins for disease research and drug discovery. MS analysis is a fundamental tool for proteomic research. In addition to LC/MS instruments for identifying and quantifying proteins in biological samples Agilent has developed wide range of complementary technologies to help researchers prepare separate analyze identify and interpret challenging protein samples.
This rapidly growing area of life science research is the study of small molecules known as “metabolites” which are products of metabolism in tissues. The makeup of these sets of molecules is increasingly being associated with a number of illnesses. GC/MS and LC/MS are the main analytical techniques to detect and measure large numbers of metabolites. Agilent also offers the METLIN personal metabolite database to help users identify the metabolites they find and profiling software to compare large sets of metabolite data to one another.
The ability to identify and quantify pollutants is essential to maintaining a health environment. A mainstay of environmental testing GC/MS is used to detect volatile organic compounds such as pesticides. Agilent is the worldwide leader in GC/MS. Inductively coupled plasma mass spectrometry (ICP-MS) helps identify and quantify inorganic compounds and heavy metals. LC/MS is a popular complement to GC/MS; it can analyze more fragile chemicals that may not stand up well to GC/MS analysis.
GC/MS LC/MS and ICP-MS are widely employed for food safety testing which includes the analysis of additives residues contaminates and toxins in agricultural products and foods. The need for food testing is growing rapidly driven by the liberalization of global trade a more stringent regulatory environment and increased public awareness of food safety issues.
Mass spectrometry has long been a mainstay in applications that involve the analysis of small thermally stable organic compounds inorganic compounds and metals. More recently the development of new technology has dramatically increased the ability of mass spectrometers to analyze large relatively fragile biological molecules such as proteins opening vast new applications for MS. Important applications and markets for MS include:
Agilent is the worldwide leading provider of GC/MS systems for drug screening and toxicology. As with the environmental industry Agilent LC/MS systems are beginning to be employed for forensic analyses as a complement to GC/MS. ICP-MS coupled to laser ablation (LA-ICP-MS) is also useful for measuring solid samples as well as for elemental fingerprinting of materials in forensic investigations
Hydrocarbon Processing Industries (HPI)
HPI comprises the petroleum petrochemical fine and specialty chemical natural gas industrial gas and fuel cell industries. Agilent mass spectrometers particularly GC/MS systems are routinely used process performance in QA/QC and process control.