Coagulation Products

Bio Data
  PAP 4-C Aggregation Profiler

bioMerieux

  Coag-A-Mate MTX
  Coag-A-Mate XM

Diagnostic Stago

  ST4

IL

  IL ACL 100     Coagulation Analyzer
  IL ACL 1000   Coagulation Analyzer
 

MLA

  MLA Electra 1400C Coagulation Analyzer
  MLA Electra 1600C Coagulation Analyzer
  MLA Electra 1800C Coagulation Analyzer

TOA

  CA 1000
  CA 5000

GMI has a coagulation expert on staff to assist in the proper instrument purchase best suited to your specific requirements.
 Please call GMI at 763-712-8717

Have you visited our Histology Center of Excellence ?
 

ACL 100 Coagulation Analyzer

GMI carries a full line of Hematology, Histology, Blood Gas
 and Coagulation products.
 Don't see what your looking for? Please call 763-712-8717
or fill out our contact form
and we will be happy to assist you.

       
          Basophil                  Eosinophil                 Lyphocyte                   Monocyte               Neutrophil
   
The Importance of Coagulation....

The ability of the body to control the flow of blood following vascular injury is paramount to continued survival. The process of blood clotting and then the subsequent dissolution of the clot, following repair of the injured tissue, is termed hemostasis. Hemostasis, composed of 4 major events that occur in a set order following the loss of vascular integrity:

·         1. The initial phase of the process is vascular constriction. This limits the flow of blood to the area of injury.

·         2. Next, platelets become activated by thrombin and aggregate at the site of injury, forming a temporary, loose platelet plug. The protein fibrinogen is primarily responsible for stimulating platelet clumping. Platelets clump by binding to collagen that becomes exposed following rupture of the endothelial lining of vessels. Upon activation, platelets release adenosine-5'-diphosphate, ADP and TXA₂ (which activate additional platelets), serotonin, phospholipids, lipoproteins, and other proteins important for the coagulation cascade. In addition to induced secretion, activated platelets change their shape to accommodate the formation of the plug.

·         3. To insure stability of the initially loose platelet plug, a fibrin mesh (also called the clot) forms and entraps the plug. If the plug contains only platelets it is termed a white thrombus; if red blood cells are present it is called a red thrombus.

·         4. Finally, the clot must be dissolved in order for normal blood flow to resume following tissue repair. The dissolution of the clot occurs through the action of plasmin.

Two pathways lead to the formation of a fibrin clot: the intrinsic and extrinsic pathway. Although they are initiated by distinct mechanisms, the two converge on a common pathway that leads to clot formation. The formation of a red thrombus or a clot in response to an abnormal vessel wall in the absence of tissue injury is the result of the intrinsic pathway. Fibrin clot formation in response to tissue injury is the result of the extrinsic pathway. Both pathways are complex and involve numerous different proteins termed clotting factors.